Endocannabinoids in synaptic plasticity and neuroprotection

Chu Chen, Ph.D.- LSUHSC School of Medicine Endocannabinoid signaling in neuroinflammation, neuroprotection, synaptic plasticity, learning and memory; Mechanisms of marijuana-altered synaptic and cognitive function, and cannabinoid tolerance. Research Interests Inflammation is now believed to be a common mechanism of disease.

Endocannabinoids and Their Implications for Epilepsy ... Dec 01, 2003 · Synaptic potentials normally too weak to induce LTP can do so when inhibition is pharmacologically blocked. DSI is a transient form of disinhibition, and indeed, weak excitatory potentials that occur during DSI induce LTP . LTP did not occur if CB1s were blocked. Hence, endocannabinoids can regulate synaptic plasticity.

Jan 31, 2005 · The cannabinoid CB 1 receptor allows endocannabinoids to act as intercellular and retrograde messengers in the central nervous system. Endocannabinoid actions have been implicated in both synaptic plasticity and neuroprotection. Here, cannabinergic activation of extracellular signal regulated-kinase (ERK) and focal adhesion kinase (FAK) occurred correspondingly in long-term …

Endocannabinoids in synaptic plasticity and neuroprotection

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Importantly, eCBs can control both inhibitory synaptic transmission (a process This neuroprotective nature of cannabinoids arises not only from their Keywords: Antiepileptic, Cannabinoids, Epilepsy, Neuroprotection, Cannabis sativa. In the CNS, ECs are involved in short and long-term synaptic plasticity Endocannabinoids in Synaptic Plasticity and Neuroprotection Endocannabinoids (eCBs) are endogenous lipid mediators involved in a variety of physiological, pharmacological, and pathological processes. While activation of the eCB system primarily induces inhibitory effects on both GABAergic and glutamatergic synaptic transmission and plasticity through acting on presynaptically-expressed CB1 receptors in the brain, accumulated information suggests … Endocannabinoids in Synaptic Plasticity and Neuroprotection [2] It has been well recognized that 2-AG is a retrograde messenger modulating synaptic transmission and plasticity at both inhibitory GABAergic and excitatory glutamatergic synapses in the brain. Endocannabinoids in Synaptic Plasticity and Neuroprotection Feb 25, 2014 · Endocannabinoids (eCBs) are endogenous lipid mediators involved in a variety of physiological, pharmacological, and pathological processes.

Clinical Neurology: Synaptic effects of cannabinoids Endocannabinoids may also act via postsynaptic CB 1 Rs and, in the case of anandamide, also transient receptor potential, vanilloid type 1 (TRPV1) channels. Endocannabinoids also mediate interactions among neurons and different types of glial cells, regulating not only synaptic plasticity but also inflammatory responses in the CNS. Endocannabinoids In The Retina: From Marijuana To ... The effects on synaptic plasticity and neuroprotection appear to depend on retrograde transmission in which postsynaptic dendrites release an eCB that binds to presynaptic CB1 receptors to reduce transmitter release (Wilson and Nicoll, 2001).

Xu JY(1), Chen 25 Feb 2014 Recent studies show that a long-lasting potentiation of excitatory synaptic transmission at Schaffer collateral (SC)-CA1 synapses is induced by Endocannabinoids (eCBs) are endogenous lipid mediators involved in a variety of physiological, pharmacological, and pathological processes. While activation 8 Mar 2019 endocannabinoids) and the enzymatic machinery for endocannabinoid synthesis and memory formation and NMDAR-dependent synaptic plasticity (2015) Neurocampus nabinoid receptors with neuroprotective activity. This paper will review the use of cannabinoids in glaucoma, presenting Xu and C. Chen, “Endocannabinoids in synaptic plasticity and neuroprotection,” The 19 Dec 2017 and prevent long-term potentiation (LTP) of synaptic transmission, but the The continuous activation of CB1Rs via exogenous cannabinoids, or by Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice Download Citation | Synaptic effects of cannabinoids: Complexity, behavioral regulating not only synaptic plasticity but also inflammatory responses in the CNS . and pain processing and participate in the mechanism of neuroprotection. Endocannabinoid signaling in neuroinflammation, neuroprotection, synaptic plasticity, learning and memory; Mechanisms of marijuana-altered synaptic and 3 Nov 2004 Lowering inhibitory synaptic transmission significantly increases the amplitude of The endocannabinoid system in this brain region has been shown to be induces neuroprotection by enhancing gabaergic transmission. The neuroprotective effects of endocannabinoids are mediated through a variety are implicated in the regulation of emotional behaviour and synaptic plasticity Several other forms of synaptic plasticity were subsequently reported to be of endocannabinoids in synaptic transmission, and the retrograde scenario has KEYWORDS: Tetrahydrocannabinol, neuroprotection, neurotoxicity, cognitive Watanabe M. Endocannabinoid-mediated control of synaptic transmission. 30 Jan 2018 The neuroprotective properties of cannabinoids suggest their (2003) It could be habit forming: drugs of abuse and striatal synaptic plasticity.

While activation of the eCB system primarily induces inhibitory effects on both GABAergic and glutamatergic synaptic transmission and plasticity through acting on presynaptically expressed CB1 receptors in the brain, accumulated information … Lipid signaling: Sleep, synaptic plasticity, and ... In the present article, we will briefly review bioactive lipids involved in sleep, synaptic transmission and plasticity, and neuroprotection, focusing mainly on our experimental studies and how these signaling molecules are related to functions and implicated in some neurologic disorders. Endocannabinoids in the Retina: From Marijuana to ... Marijuana and the Endocannabinoids. The effects on synaptic plasticity and neuroprotection appear to depend on retrograde transmission in which postsynaptic dendrites release an eCB that binds to presynaptic CB1 receptors to reduce transmitter release (Wilson and Nicoll, 2001).

Omega-3 (ω-3) and omega-6 (ω-6) are polyunsaturated fatty acids (PUFAs) that play critical role in human health and have to be provided by food. In the brain, PUFAs are also precursors of endocannabinoids. The aim of this chapter is to review the existing literature on how dietary PUFAs impact on the endocannabinoid system in the brain and what are the consequences for brain function and Endocannabinoid-Specific Impairment in Synaptic Plasticity ... Jan 17, 2018 · Impaired hippocampal synaptic plasticity has been documented in HD mouse models. Less is known about the impact of the HD mutation on synaptic plasticity at corticostriatal synapses, which show early changes in basal synaptic transmission in several HD mouse models.

Neuroinflammation, the inflammatory response that Frontiers | Dual Influence of Endocannabinoids on Long ... Dec 19, 2017 · Cannabinoid receptor 1 (CB1R) is widely distributed in the central nervous system, in excitatory and inhibitory neurons, and in astrocytes.

Dec 19, 2017 · Cannabinoid receptor 1 (CB1R) is widely distributed in the central nervous system, in excitatory and inhibitory neurons, and in astrocytes. CB1R agonists impair cognition and prevent long-term potentiation (LTP) of synaptic transmission, but the influence of endogenously formed cannabinoids (eCBs) on hippocampal LTP remains ambiguous. Based on the knowledge that eCBs are released … Neurochemical Communication: The Case of Endocannabinoids receptors is linked to the use of endocannabinoids to deliver or fine-tune their messages to target cells [11]. The discovery of DSI has been a major advance in our understanding of the endocannabinoid system for brain function [60].